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HIV and Its TransmissionResearch has revealed a great deal of valuable medical, scientific

HIV and Its Transmission

Research has revealed a great deal of valuable medical, scientific, and public health information about the human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). The ways in which HIV can be transmitted have been clearly identified. Unfortunately, false information or statements that are not supported by scientific findings continue to be shared widely through the Internet or popular press. Therefore, the Centers for Disease Control and Prevention (CDC) has prepared this fact sheet to correct a few misperceptions about HIV.

How HIV Is Transmitted

HIV is spread by sexual contact with an infected person, by sharing needles (primarily for drug injection) with someone who is infected, or, less commonly, through transfusions of infected blood or blood clotting factors (凝血因子). Babies born to HIV-infected women may become infected before or during birth or through breast-feeding after birth.

Some people fear that HIV might be transmitted in other ways; however, no scientific evidence supporting any of these fears has been found. If HIV were being transmitted through other routes (such as through air, water, or insects), the pattern of reported AIDS cases would be much different from what has been observed. For example, if mosquitoes could transmit HIV infection, many more young children and preadolescents would have been diagnosed with AIDS.

All reported cases suggesting new or potentially unknown routes of transmission are thoroughly investigated by state and local health departments with the assistance, guidance, and laboratory support from CDC. No additional routes of transmission have been recorded, despite a national sentinel (监测) system designed to detect just such an occurrence.

The following paragraphs specifically address some of the common misperceptions about HIV transmission.

HIV in the Environment

Scientists and medical authorities agree that HIV does not survive well in the environment, making the possibility of environmental transmission remote. HIV is found in varying concentrations or amounts in blood, semen (精液), vaginal (阴道的) fluid, breast milk, saliva (唾液), and tears. To obtain data on the survival of HIV, laboratory studies have required the use of artificially high concentrations of laboratory-grown virus. Since the HIV concentrations used in laboratory studies are much higher than those actually found in blood or other specimens, drying of HIV-infected human blood or other body fluids reduces the theoretical risk of environmental transmission to that which has been observed—essentially zero. Incorrect interpretation of conclusions drawn from laboratory studies has unnecessarily alarmed some people.

Results from laboratory studies should not be used to assess specific personal risk of infection because: (1) The amount of virus studied is not found in human specimens or elsewhere in nature, and (2) no one has been identified as infected with HIV due to contact with an environmental surface. Additionally, HIV is unable to reproduce outside its living host except under laboratory conditions. Therefore, it does not spread or maintain infectiousness outside its host.

Households

Although HIV has been transmitted between family members in a household setting, this type of transmission is very rare. These transmissions are believed to have resulted from contact between skin or mucous membranes (黏膜) and infected blood. To prevent even such rare occurrences, precautions should be taken in all settings "including the home" to prevent exposure to the blood of persons who are HIV infected, at risk for HIV infection, or whose infection and risk status are unknown, For example.

Gloves should be worn during contact with blood or other body fluids that could possibly contain vis

A.Y

B.N

C.NG

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更多“HIV and Its TransmissionResearch has revealed a great deal of valuable medical, scientific”相关的问题

第1题

听力原文:After years of failing to take the disease seriously, Beijing has become a late c

听力原文: After years of failing to take the disease seriously, Beijing has become a late convert to the cause of HIV/Aids education, prevention and treatment.

In recent months health authorities have stepped up plans to distribute free condoms, promote needle exchanges, provide free antiretroviral drugs to patients and boost Aids awareness through education campaigns. Yet, Beijing had better be ready for an epic battle if it is to prevent a full-scale crisis. Already, more than 200,000 people have died of Aids in China and a further 840,000 axe living with HIV/Aids. The UN warns that, unchecked, the disease could claim 10 million victims by 2010.

The world's first HIV case was discovered in America in 1981. Four years later, China discovered its first HIV case. However, long after that, ignorance about how the disease is transmitted remains widespread. Disseminating knowledge of how HIV is transmitted and finding ways to cheaply distribute antiretroviral drugs for infected patients are among tasks facing health authorities, who are now applied to preventing an oncoming disaster.

Although China is coming late to the Aids war, it can benefit from the experience of other countries and it can also benefit from the increased global funding and willingness to share expertise that is available today. Therefore, we have a good reason to believe that China will eventually succeed in its effort to restrain the spread of Aids.

(33)

A.It's bound to end in failure.

B.It's arduous, yet promising.

C.It's hard to predict the final outcome.

D.It will go smoothly.

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第2题

Once-daily Pill Could Simplify HIV TreatmentBristol-Myers Squibb and Gilead Sciences have

Once-daily Pill Could Simplify HIV Treatment

Bristol-Myers Squibb and Gilead Sciences have combined many HIV drugs into a single pill. Sometimes the best medicine is more than one kind of medicine. Malaria, tuberculosis and HIV/ AIDS, for example, are all treated with (51) of drugs. But that can mean a lot of pills to take. It would be (52) if drug companies combined all the medicines into a single pill, taken just once a day.

Now, two companies say they have done that for people just (53) treatment for HIV, the virus, that causes AIDS. The companies are Bristol-Myers Squibb and Gilead Sciences. They have (54) a single pill that combines three drugs currently on the market. Bristol-Myes Squibb sells one of them (55) the name of Sustiva. Gilead combined the (56) , Emtriva and Viread, into a single pill in two thousand four.

Combining drugs involves more than (57) issues. It also involves issues of competition (58) the drugs are made by different companies. The new once-daily pill is the result of (59) is described as the first joint venture agreement of its kind in the treatment of HIV.

In January the New England Journal of Medicine published a study of the new pill. Researchers compared its (60) to that of the widely used combination of Sustiva and Combivir. Combivir (61) two drugs, AZT and 3TC. The researchers say that after one year of treatment, the new pill suppressed HIV levels in more patients and with (62) side effects. Gilead paid for the study. Professor Joel Gallant at the Johns Hopkins School of Medicine in Baltimore, Maryland, led the research.

Glaxo Smith Kine reacted (63) the findings by saying that a single study is of limited value. It says the effectiveness of Combivir has been shown in each of more than fifty studies.

The price of the new once-daily pill has not been announced. But Gilead and Bristol-Myers Squibb say they will provide it at reduced cost to developing countries. They plan in the next few months to ask the United States Food and Drug Administration to (64) the new pill.

There are limits to who could take it because of the different drugs it contains. For example, (65) women are told not to take Sustiva because of the risk of birth disorders. Experts say more that forty million people around the world are living with HIV.

(51)

A.conservation

B.cooperation

C.combinations

D.considerations

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第3题

Since the US Agency for International Development (USAID) began its first HIV/AIDS prevent

Since the US Agency for International Development (USAID) began its first HIV/AIDS prevention efforts eight years ago, the epidemic has changed dramatically. HIV has spread to every region of the world. Millions of people infected with HIV during the first decade of the epidemic are developing opportunistic infections and other AIDS-related illnesses, and many are dying. Women and children are among those most vulnerable to HIV infection. As HIV prevalence and AIDS mortality soar, millions of children will lose their parents.

HIV/AIDS is having a devastating impact on the health and well-being of families, communities and nations worldwide. The epidemic's effects on the structure of societies and the productivity of their members undermine efforts to promote sustainable development around the globe.

USAID's approach to slowing the spread of HIV/AIDS relies on strategies tested and refined over the past eight years. At the same time, the Agency is moving forward to address new challenges posed by the evolving epidemic.

One of the important lessons learned during the past decade is that an effective response to HIV/ AIDS requires the full participation of people and communities affected by the virus. Although people living with HIV/AIDS are among the most successful advocates and communicators for prevention, too often their voices are not heard or heeded. Greater involvement of people living with HIV/AIDS is essential to creat the supportive political, legal and social environments needed to control the epidemic.

In December 1994 at the Paris AIDS Summit, representatives of 42 governments adopted resolution pledging greater support for networks of people living with HIV/AIDS. Before and during the summit, members of these networks worked with government and multilateral organizations, including USAID, to develop a plan for translating the words of the resolution into concrete action. The Agency is committed to ensuring that people living with HIV/AIDS are accepted in full partnership with governments, international organizations and the private sector in developing, implementing and evaluating HIV/AIDS policies and programs.

People living with HIV/AIDS and community-based organizations have been at the forefront of efforts to draw attention to the connection between compassionate AIDS care and effective HIV prevention. In the absence of a vaccine or cure, USAID continues to emphasize HIV/AIDS prevention. But as the number of people suffering from AIDS-related illness begins to increase dramatically, the Agency is also exploring ways to reduce the social impact of AIDS and enhance prevention efforts by integrating prevention and care.

The Agency will also continue to pioneer regional approaches to an epidemic that does not recognize national boundaries. Crossborder interventions throughout the world will target mobile populations, including migrant workers, tourists, traders, transport workers and people displaced by war, and social disruption.

Results from USAID-supported research on preventing HIV/AIDS in women, from microbiocide development to behavioral research on communication between men and women, will play a key role in slowing the rapid spread of the epidemic in the future. The Agency will continue to support research designed to strengthen programs for women and will move quickly to incorporate promising prevention methods into field activities. USAID will also work to reduce women's vulnerability to HIV prevention by promoting multisectoral efforts to improve their economic and social status.

Recognizing the growing threat HIV/AIDS poses to child survival, the Agency will support efforts to identify and test methods of preventing transmission from mother to child, such as Vitamin A supplements and other promising interventions. In addition, USAID will expand efforts to reduce HIV/ AIDS am

A.Y

B.N

C.NG

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第4题

On the 20th【D1】______ of the first official report on AIDS the head of the United Nations
AIDS programme warns the deadly disease may only be at its early stages in many parts of the world. Dr. Piot has said that the disease has already reached the【D2】______【D3】______ since first being【D4】______ in 1981. 58 million people world-wide have【D5】______ the HIV virus,which causes AIDS, while 22 million have 【D6】______related【D7】______. The UN estimates the worlds HIV-【D8】______ population at 36 million, including 25 million in Sub-Saharan Africa. International officials warned that the disease would have【D9】______ political, social and economic【D10】______ in many developing countries.

【D1】

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第5题

Among the devastating consequences of AIDS has【21】______ its epidemic spread in the develo

Among the devastating consequences of AIDS has 【21】______ its epidemic spread in the developing world. The disease has caused 【22】______ suffering, debilitation, loss of life and disruption of family, social and economic 【23】______ Because of the considerable expense and logistical difficulty in providing antiviral drugs to populations 【24】______ with the Human Immunodeficiency Virus 【25】______ the world, the biomedical community is looking towards vaccines to help solve this compelling problem.

The search for an AIDS vaccine began more than 15 years ago with great 【26】______ and high expectations. With the 【27】______ of the Human Immunodeficiency Virus (HIV) as the cause of AIDS, it seemed that a 【28】______ would follow closely behind. But despite a large concerted effort, the problem has proven more difficult than 【29】______ , and progress has not 【30】______ the 【31】______ hopes. Here I review the 【32】______ scientific obstacles confronting the development of an effective HIV vaccine, and I consider 【33】______ strategies to overcome these obstacles.

It is instructive to consider the circumstances that have 【34】______ to past successes in vaccine development. The smallpox vaccine is 【35】______ the most successful inventions in the history of 【36】______ Why, 200 years ago, without the benefit of modern biotechnology, did the smallpox vaccine succeed so readily while an AIDS vaccine 【37】______ elusive? The answer lies in an experiment of nature that provided, to an astute observer, a clear direction for smallpox vaccine development. In this classic story of 【38】______ discovery, Edward Jennet noticed that milk maids who had previously contracted cowpox were 【39】______ to smallpox infection. This observation was the critical event leading to the finding that the cowpox virus cross-reacted immunologically with the smallpox virus and could 【40】______ be used to protect against smallpox.

【21】

A.on

B.with

C.been

D.about

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第6题

A. Wal-Mart cuts sales forecastWal-Mart Stores, Inc. cut its August sales forecast Monday,

A. Wal-Mart cuts sales forecast

Wal-Mart Stores, Inc. cut its August sales forecast Monday, saying it expects sales at stores open at least a year to be flat to up 2 percent, citing weak back-to-school trends and hurricanes that forced it to close up to 75 stores. Wal-Mart had been forecasting that sales at stores open at least a year, known as same-store sales, would rise 2 to 4 percent for the month. Wal-Mart stock fell about 2 percent in morning trading on the New York Stock Exchange.

B. El Paso sees $ 2. 7B drop in assets

El Paso Corp. on Monday disclosed the full damage from its drastic cut in reserves earlier this year, saying a long-awaited restatement will slash the value of its oil and gas assets by $ 2.7 billion. The Houston company, the largest U.S. natural gas pipeline operator, also said it expects to cut its debt by 9 percent from its current level to under $17 billion by year-end. El Paso, which earlier this year cut its proven natural gas reserves by 41 percent and said it would restate earnings back to 1999, had about $ 2. 7 billion in cash and credit revolvers as of July 31.

C. FedEx shares rise on outlook

FedEx Corp. raised its earnings forecast for the fiscal first quarter and frill year Monday, citing strong demand for its international express, ground and less-than-truckload services. Shares of FedEx rose as much as 3:7 percent in the first half of Monday's New York Stock Exchange trading. Chief Financial Officer Alan Graf said risks existed, such as prolonged high oil prices, that could hurt the world economy, but the company expects its business to remain strong.

D. IBM sees 30% gain in Web hosting

International Business Machines Corp. widened its lead last year in the U. S. market for Internet hosting services as it won a greater share of the medium-sized business market, according to data recently published by market research firm IDC. The Armonk, N. Y. - based company has identified Web hosting as a key to boosting overall revenue growth. As the hardware business that had been its mainstay has matured over the past several years, IBM has focused on services. According to the most recent report from IDC, published in late July, IBM's Web hosting market share in the United States rose to 24.8 percent in 2003 from 23.5 percent in 2002 and just 15 percent in 2000.

E. Viagra abuse may boost HIV risk

San Francisco has petitioned federal regulators to warn that use of anti-impotence drugs such as Viagra could increase the risk of sexually transmitted disease and HIV, officials said on Monday. The request to the Food and Drug Administration earlier this month is a response to the recreational use of Viagra among gay men, who use it to enhance promiscuous sex. "The predominant problem that we see in San Francisco is with widespread use among gay men with multiple partners," said Jeffrey Klausner, director of sexually transmitted disease prevention at the city's health department.

The company has decreased its expectation of turnover.

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第7题

A newly published AIDS study could open another front in the battle against HIV infection
by showing that gene therapy can be used to stop infected cells from spreading the deadly virus, researchers said.

In a test-tube experiment believed to be the first of its kind, researchers based at Children's Hospital of Philadelphia were able to block the operation of the" tat "gene that allows HIV to spread throughout the body from infected cells.

Up to now, genetic AIDS research has concentrated on finding ways to help healthy cells withstand the ravages of the HIV virus that infects an estimated 16, 000 new victims a day, mainly in the developing world.

But by working with human cells already infected with HIV, the team was able to reduce the tat gene's virus-replicating functions by 80 percent to 90 percent, according to findings published in the journal Gene Therapy.

That, researchers said, raises the possibility of a new gene therapy approach capable of supplementing the current drug-based treatment known as highly active anti-retroviral therapy, or HAART, which is used to stop HIV infection from becoming full-blown AIDS.

In recent studies, HAART has proved to be a costly drug regimen that poses serious side effects for HIV patients while delivering questionable results.

"This is proof of the concept that HIV replication could be inhibited by a genetic approach, though we're not at 100 percent yet, "said Dr. Stuart Starr, a study coauthor and chief of immunologic infectious diseases at Children's Hospital.

"Everyone thinks of an antiviral approach, or an immunologic approach to HIV. This adds another option into the equation that could become more important as other options prove not to be totally successful."

Key to the study was an artificially produced" antitat" gene provided by the Washington-based Research Institute for Genetic and Human Therapy.

Children's Hospital researchers used a mouse retrovirus to deliver the antitat gene into HIV-infected U-1 and ACH-2 cells, which were developed in the lab from the tissues of living HIV patients.

They found that when the antitat protein combined with the tat gene, it successfully inhibited the gene's operation without disturbing healthy cells or causing toxic side-effects.

The study, funded by a private foundation, also found that the introduction of the antitat gene prolonged the survival of immune-system cells called CD4 + T lymphocytes.

Start said researchers have entered preliminary discussions with a New England-based primate center ,where animal experiments could be carried out on infected macaque monkeys.

If animal experiments proved successful, the Children's Hospital team would hope to have a gene therapy treatment ready for human clinical trials in three to four years.

What is the passage mainly about?

A.AIDS study raises hopes for gene therapy treatment.

B.A new killer of HIV virus.

C.Research on gene therapy.

D.Gene therapy proves to be the ultimate solution to HIV infection.

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第8题

Once Daily Pill Could Simplify HIV Treatment ??Bristol-Myers Squibb and Gilead Scienceshav

Once Daily Pill Could Simplify HIV Treatment

?? Bristol-Myers Squibb and Gilead Scienceshave combined many HIV drugs into a single pill. Some- times the best medicineis more than one kind of medicine. Malaria, tuberculosis andHIV/AIDS,___________ (51), are all treated with combinations of drugs. But thatcan mean a lot of pill to take. It wouldbe _______________ (52) drug companiescombined all the medicines into a single pill, taken just once a day.??

?? Now,two companies say they have done that for people just ___ (53) treatment for HIV, the virus that causesAIDS. The companies are Bristol-Myers Squibb and Gilead Science. They have ___________(54) a single pill that combinesthree drugs currently on the market. Bristol-Myers Squibb sells one of them___________ (55) the name of Sustiva. Gilead combined the ________________(56), Emtriva and Viread, into a single pill in two thousand four.??

?? Combining drugs involves more than _________(57) issues. It alsoinvolves issues of competition _______(58) the drugs are made by different companies. The newonce-daily pill is the result of _________(59) is described as the first joint venture agreement of itskind in the treatment of HIV. In January the New England Journal of Medicinepublished a study of the new pill. Researcher compared its _(60) to that of the widely usedcombination of Sustiva and Combivir. Combivir ________ (61) two drugs, AZT and3TC. The researchers say that after one year of treatment, the n ew pill sup-pressed HIV levels in more patients and with fewer ________________(62)effects. Gilead paid for the study. Professor Joel Gallant at the Johns HopkinsSchool of Medicine in Baltimore, Maryland, led the re- search. He is a paidadviser to Gilead and Bristol-Meyers Squibb as well as the maker of Combivir,G1- axo Smith Kline.??

??GlaxoSmith Kline reacted ___(63) the findings by saying that a single study is oflimited value. It says the effectiveness of Combivir has been shown in each ofmore than fifty studies. The price of the new once-daily pill has not been announced.But Gilead and Bristol-Myers Squibb say they will provide it at reduced cost todeveloping countries. They plan in the next few months to ask the United

?? States Foodand Drug Administr??ation to approve the new pill.,??

??There are limits to who could take it __(64) the different drugs itcontains. For example, __________(65) women are told not to take Sustivabecause of the risk of birth disorders. Experts say more than forty millionpeople around the world are living with HIV.

51??

A.therefore

B.thus

C.for example

D.nevertheless

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第9题

By drawing on the World Banks projections of socioeconomic development over the next qua
rter century, researchers at the World Health Organization set out to forecast global trends in death and disease. Among the grim catalog of predictions are that 【M1】______ the current top two killers — heart disease and stroke — will hold on to their rankings. By 2030, however, HIV/AIDS will move up from its current ranking in fourth place to become the third- leading cause of death around the globe. One of the obvious consequences of increased development will be more deaths and injuries from traffic accidents, but 【M2】______ tobacco-related deaths are also expected to surge, accounted for 【M3】______ 10 percent of all fatalities by 2015. In the fact, WHO estimates 【M4】______ that 50 percent more people will die with illnesses due to tobacco 【M5】______ use than from AIDS that year, although tobacco itself is not listed as a cause of death. Deaths from tobacco-related conditions will be split fairly evenly among cancers, cardiovascular diseases, and respiratory illnesses. The report, that is the most comprehensive of its kind, 【M6】______ does contain some bright spots. For example, it predicts that maternal deaths associated with pregnancy and childbirth will become more common, as will infant mortality and deaths 【M7】______ from nutritional causes. Because increased prosperity and 【M8】______ better medical care, the risk of death for children younger than 5 is projecting to decrease by more than 40 percent by 2030. 【M9】______ The death rate from tuberculosis, malaria, and other non-HIV infectious disease will also decline. And people all over the 【M10】______ world will be living longer lives, with the largest gains occurring in Africa and South Asia.

【M1】

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第10题

ChimpanzeesChimpanzees(黑猩猩) will soon be extinct(灭绝). If the present rate of hunting

Chimpanzees

Chimpanzees(黑猩猩) will soon be extinct(灭绝). If the present rate of hunting and habitat(栖息地) destruction continues, then within 20 years, there will be no chimpanzees living in the wild. But this is more than an environmental or moral tragedy(悲剧). Chimpanzee extinction may also have profound implications(含意) for the survival of their distant relatives—human beings.

In 1975 the biologist Marie-Claire King and Allan Wilson discovered that the human and chimpanzee genomes(基因组) match by over 98%. Compare this to the mouse, used as model for human disease in lab tests, which shares only 60% of its DNA with us. In fact, chimpanzees are far more similar to humans than they are to any other species of monkey. As well as resembling us genetically, chimps are highly intelligent and able to use tools. These facts alone should be enough to make protection of chimps an urgent priority (优先). But there is another, more selfish reason to preserve the chimp.

The chimpanzees' trump card(王牌) comes in the field of medical research. Chimpanzees are so similar to humans that veterinarians(兽医) often refer to human medical textbooks when treating them. Yet chimpanzees do show differences in several key areas. In particular, chimps are much more resistant to a number of major diseases. It is this ability that is so interesting.

For example, chimps seem to show a much higher resistance than humans to HIV, the virus that causes Aids. Indeed, their use as experimental animals in Aids research has declined because they are so resistant.

By sequencing the chimp genome and pinpointing(找到) the place where the chimpanzee DNA sequence differs from that of humans, scientists hope to be able to discover which part of the genetic code gives chimps their increased resistance to some diseases. This, they hope, will allow them to develop new and more effective treatments for the human forms of these diseases. Such treatments could include the production of new drugs or even the alteration(改变) of the human genetic sequence. The recently completed human genome sequencing project has shown that such an effort is now well within our reach.

A. Reasons for HIV resistance

B. Implications of chimpanzee extinction for humans

C. Effective Aids treatment

D. Genetic similarities between chimps and humans

E. Resistance to HIV

F. Genetic differences between chimps and humans

Paragraph 1 ______

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